T-LYMPHOCYTES IN IgA DEFICIENCY
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چکیده
Common variable immunodeficiency (CVID) and IgA deficiency (IgAD) are primary humoral immune deficiencies with a similar genetic background, but clinical and laboratory manifestation of CVID is much more severe than that of IgAD. The aim of this study was to determine whether some abnormalities in T-lymphocyte subsets or function observed in CVID are also present in IgAD patients. T-lymphocyte subsets (CD3+, CD4+, CD8+, CD4+CD45RA+, CD4+CD45RO+ and CD8+CD57+) were studied in 61 adult IgAD patients and in 43 control, healthy subjects. In the IgAD patients, a significant decrease in CD4+ and an increase in CD8+ and CD8+CD57+ lymphocytes were observed but no significant changes in the proportion of CD45RA+ or CD45RO+ in CD4+ cells were detected. No significant changes in lymphocyte proliferation after stimulation with Phytohaemagglutinin, Concanavalin-A or tetanic toxoid were observed in 15 adult IgAD patients compared to 15 controls. Our study showed that T-lymphocyte abnormalities were present in IgAD patients, although not to such a broad extent as in CVID.
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